1) Astronomers
detect evidence of universe's 'background hum':
The breakthrough was
hailed as a major milestone that opens a new window into the universe.
Astronomers across the
world announced on Thursday that they have found the first evidence of a
long-theorised form of gravitational waves that create a "background
hum" rumbling throughout the universe. The breakthrough -- made by
hundreds of scientists using radio telescopes in North America, Europe, China,
India and Australia after years of work -- was hailed as a major milestone that
opens a new window into the universe.
First predicted by
Albert Einstein more than a century ago, gravitational waves are ripples in the
fabric of the universe that travel through everything at the speed of light
almost entirely unimpeded.
Their existence was not
confirmed until 2015, when the US and Italian observatories detected the first
gravitational waves created by two black holes colliding.
These
"high-frequency" waves were the result of a single violent event that
sends a strong, short burst rippling towards Earth.But for decades scientists
have been searching for low-frequency gravitational waves, thought to be
constantly rolling through space like background noise. Joining forces under
the banner of the International Pulsar Timing Array consortium, scientists
working at gravitational wave detectors on several continents revealed on
Thursday they have finally found strong evidence of these background waves.
"We now know that
the universe is awash with gravitational waves," Michael Keith of the
European Pulsar Timing Array told AFP.
Using dead stars as clocks -
As gravitational waves
travel through space, they very subtly squeeze and stretch everything they pass
through.To find evidence of this squeezing and stretching at low frequencies,
astronomers looked at pulsars, the dead cores of stars that exploded in a
supernova.Some spin hundreds of times a second, flashing beams of radio waves
at extremely regular intervals, like cosmic lighthouses.This means they can act
as "a very, very precise clock," Keith said. For the new research,
radio telescopes around the world were aimed at a total of 115 pulsars
throughout the Milky Way.
Scientists then measured
the incredibly small differences in the timing of the pulses, searching for
telltale signs of gravitational waves.French astrophysicist Antoine Petiteau
said they were able to "detect changes of less than one millionth of a
second across more than 20 years".Maura McLaughlin of the US Pulsar Search
Collaboratory programme said they were "awestruck" after first seeing
evidence of the waves in 2020.It was "really a magical moment," she
told a press conference.
The early evidence was
consistent with Einstein's theory of relativity and science's current understanding
of the universe, the scientists said.But they emphasised they have not yet
definitively "detected" the waves, because they have not reached the
gold-standard five sigma level of certainty. Five sigma indicates that there is
a one-in-a-million chance of something being a statistical fluke. "We're
frustratingly just shy of the mark," Keith said, adding that there was a
99-percent probability that the evidence points to gravitational waves.
Each country or group in
the consortium published their research separately in a range of journals.Steve
Taylor, chair of North America's NANOGrav gravitational wave observatory, said
that once all the data was combined, the five sigma mark could be reached in a
year or two.
The sounds are made by objects moving and colliding in space Daniëlle Futselaarartsource.nlMaxPlanck-Institut für Radioastronomie |
'Like sitting in a noisy restaurant' -
The leading theory is
that the waves are coming from pairs of supermassive black holes sitting at the
centre of galaxies that are slowly merging.
Unlike those that caused
the previously detected gravitational waves, these black holes are almost
unimaginably huge -- sometimes billions of times bigger than the Sun.
Daniel Reardon, a member
of Australia's Parkes Pulsar Timing Array, told AFP that -- if confirmed -- the
waves would be "the sum of all of the supermassive black hole binary
systems whirling around each other at the cores of galaxies everywhere in the
universe".
Keith said the
"background hum of all these black holes" was "like sitting in a
noisy restaurant and hearing all these people talking".
Another theory is that
the gravitational waves could be from the rapid expansion that came within a
second after the Big Bang, a period called cosmic inflation that is hidden from
the view of scientists.
Keith said the galaxies
between Earth and the Big Bang were likely "drowning out" such waves.
But in the future,
low-frequency gravitational waves could reveal more about this early expansion
and possibly shed light on the mystery of dark matter, the scientists said.It
could also help them understand more about how black holes and galaxies form
and evolve.
2) New analysis of
tooth minerals confirms megalodon shark was warm-blooded :
Megalodons, which went extinct 3.6 million years ago, are believed to have grown to lengths of 50 feet |
The largest marine
predator that ever lived was no cold-blooded killer. A new analysis by
environmental scientists from UCLA, UC Merced and William Paterson University
sheds light on the warm-blooded animal's ability to regulate its body
temperature—and might help explain why it went extinct.
After analyzing isotopes
in the tooth enamel of the ancient shark, which went extinct about 3.6 million
years ago, the scientists concluded the megalodon could maintain a body
temperature that was about 13°F (about 7°C) warmer than the surrounding water.
That temperature
difference is greater than those that have been determined for other sharks
that lived alongside the megalodon and is large enough to categorize megalodons
as warm-blooded.
The paper, published in
Proceedings of the National Academy of Sciences, suggests that the amount of
energy the megalodon used to stay warm contributed to its extinction. And it
has implications for understanding current and future environmental changes.
"Studying the
driving factors behind the extinction of a highly successful predatory shark
like megalodon can provide insight into the vulnerability of large marine
predators in modern ocean ecosystems experiencing the effects of ongoing
climate change," said lead researcher Robert Eagle, a UCLA assistant
professor of atmospheric and oceanic sciences and member of the UCLA Institute
of the Environment and Sustainability.
Megalodons, which are
believed to have reached lengths up to 50 feet, belonged to a group of sharks
called mackerel sharks—members of that group today include the great white and
thresher shark. While most fish are cold-blooded, with body temperatures that
are the same as the surrounding water, mackerel sharks keep the temperature of
all or parts of their bodies somewhat warmer than the water around them,
qualities called mesothermy and regional endothermy, respectively.
Sharks store heat
generated by their muscles, making them different from fully warm-blooded or
endothermic animals like mammals. In mammals, a region of the brain called the
hypothalamus regulates body temperature.
Various lines of
evidence have hinted that megalodon might have been mesothermic. But without
data from the soft tissues that drive body temperature in modern sharks, it has
been difficult to determine if or to what extent megalodon was endothermic.
In the new study, the
scientists looked for answers in the megalodon's most abundant fossil remains:
its teeth. A main component of teeth is a mineral called apatite, which
contains atoms of carbon and oxygen. Like all atoms, carbon and oxygen can come
in "light" or "heavy" forms known as isotopes, and the
amount of light or heavy isotopes that make up apatite as it forms can depend
on a range of environmental factors. So the isotopic composition of fossil
teeth can reveal insights about where an animal lived and the types of foods it
ate, and—for marine vertebrates—information like the chemistry of the seawater
where the animal lived and the animal's body temperature.
"You can think of
the isotopes preserved in the minerals that make up teeth as a kind of thermometer,
but one whose reading can be preserved for millions of years," said Randy
Flores, a UCLA doctoral student and fellow of the Center for Diverse Leadership
in Science, who worked on the study. "Because teeth form in the tissue of
an animal when it's alive, we can measure the isotopic composition of fossil
teeth in order to estimate the temperature at which they formed and that tells
us the approximate body temperature of the animal in life."
An upper tooth from a megalodon (right) dwarfs that of a white shark |
Because most ancient and
modern sharks are unable to maintain body temperatures significantly higher
than the temperature of surrounding seawater, the isotopes in their teeth
reflect temperatures that deviate little from the temperature of the ocean. In
warm-blooded animals, however, the isotopes in their teeth record the effect of
body heat produced by the animal, which is why the teeth indicate temperatures
that are warmer than the surrounding seawater.The researchers hypothesized that
any difference between the isotope values of the megalodon and those of other
sharks that lived at the same time would indicate the degree to which the
megalodon could warm its own body.
The researchers
collected teeth from the megalodon and other shark contemporaries from five
locations around the world, and analyzed them using mass spectrometers at UCLA
and UC Merced. Using statistical modeling to estimate sea water temperatures at
each site where teeth were collected, the scientists found that megalodons'
teeth consistently yielded average temperatures that indicated it had an impressive
ability to regulate body temperature.
Its warmer body allowed
megalodon to move faster, tolerate colder water and spread out around the
world. But it was that evolutionary advantage that might have contributed to
its downfall, the researchers wrote.
The megalodon lived
during the Pliocene Epoch, which began 5.33 million years ago and ended 2.58
million years ago, and global cooling during that period caused sea level and
ecological changes that the megalodon did not survive.
"Maintaining an
energy level that would allow for megalodon's elevated body temperature would
require a voracious appetite that may not have been sustainable in a time of
changing marine ecosystem balances when it may have even had to compete against
newcomers such as the great white shark," Flores said.
Project co-leader
Aradhna Tripati, a UCLA professor of Earth, planetary and space sciences and a
member of the Institute of Environment and Sustainability, said the scientists
now plan to apply the same approach to studying other species."Having
established endothermy in megalodon, the question arises of how frequently it
is found in apex marine predators throughout geologic history," she said.
3) Humans'
evolutionary relatives butchered one another 1.45 million years ago by Smithsonian:
Researchers from the Smithsonian's National Museum of Natural History have identified the oldest decisive evidence of humans' close evolutionary relatives butchering and likely eating one another. n a new study published June 26, in Scientific Reports, National Museum of Natural History paleoanthropologist Briana Pobiner and her co-authors describe nine cut marks on a 1.45 million-year-old left shin bone from a relative of Homo sapiens found in northern Kenya. Analysis of 3D models of the fossil's surface revealed that the cut marks were dead ringers for the damage inflicted by stone tools. This is the oldest instance of this behavior known with a high degree of confidence and specificity.
"The information we
have tells us that hominins were likely eating other hominins at least 1.45
million years ago," Pobiner said. "There are numerous other examples
of species from the human evolutionary tree consuming each other for nutrition,
but this fossil suggests that our species' relatives were eating each other to
survive further into the past than we recognized."
Pobiner first
encountered the fossilized tibia, or shin bone, in the collections of the
National Museums of Kenya's Nairobi National Museum while looking for clues
about which prehistoric predators might have been hunting and eating humans'
ancient relatives. With a handheld magnifying lens, Pobiner pored over the
tibia looking for bite marks from extinct beasts when she instead noticed what
immediately looked to her like evidence of butchery.
View of the hominin tibia and magnified area that shows cut marks. Scale = 4 cm. |
To figure out if what
she was seeing on the surface of this fossil were indeed cut marks, Pobiner
sent molds of the cuts—made with the same material dentists use to create
impressions of teeth—to co-author Michael Pante of Colorado State University.
She provided Pante with no details about what he was being sent, simply asking
him to analyze the marks on the molds and tell her what made them. Pante
created 3D scans of the molds and compared the shape of the marks to a database
of 898 individual tooth, butchery and trample marks created through controlled
experiments.
The analysis positively
identified nine of the 11 marks as clear matches for the type of damage
inflicted by stone tools. The other two marks were likely bite marks from a big
cat, with a lion being the closest match. According to Pobiner, the bite marks
could have come from one of the three different types of saber-tooth cats
prowling the landscape at the time the owner of this shin bone was alive. By
themselves, the cut marks do not prove that the human relative who inflicted
them also made a meal out of the leg, but Pobiner said this seems to be the
most likely scenario. She explained that the cut marks are located where a calf
muscle would have attached to the bone—a good place to cut if the goal is to
remove a chunk of flesh. The cut marks are also all oriented the same way, such
that a hand wielding a stone tool could have made them all in succession
without changing grip or adjusting the angle of attack.
"These cut marks
look very similar to what I've seen on animal fossils that were being processed
for consumption," Pobiner said. "It seems most likely that the meat
from this leg was eaten and that it was eaten for nutrition as opposed to for a
ritual."
While this case may
appear to be cannibalism to a casual observer, Pobiner said there is not enough
evidence to make that determination because cannibalism requires that the eater
and the eaten hail from the same species.
The fossil shin bone was
initially identified as Australopithecus boisei and then in 1990 as Homo
erectus, but today, experts agree that there is not enough information to
assign the specimen to a particular species of hominin. The use of stone tools
also does not narrow down which species might have been doing the cutting.
Recent research from Rick Potts, the National Museum of Natural History's Peter
Buck Chair of Human Origins, further called into question the once-common
assumption that only one genus, Homo, made and used stone tools.
Nine marks identified as cut marks (mark numbers 1–4 and 7–11) and two identified as tooth marks (mark numbers 5 and 6) based on comparison with 898 known bone surface modifications |
So, this fossil could be
a trace of prehistoric cannibalism, but it is also possible this was a case of
one species chowing down on its evolutionary cousin.
None of the stone-tool
cut marks overlap with the two bite marks, which makes it hard to infer
anything about the order of events that took place. For instance, a big cat may
have scavenged the remains after hominins removed most of the meat from the leg
bone. It is equally possible that a big cat killed an unlucky hominin and then
was chased off or scurried away before opportunistic hominins took over the
kill. One other fossil—a skull first found in South Africa in 1976—has
previously sparked debate about the earliest known case of human relatives
butchering each other. Estimates for the age of this skull range from 1.5 to
2.6 million years old.
Apart from its uncertain
age, two studies that have examined the fossil (the first published in 2000 and
the latter in 2018) disagree about the origin of marks just below the skull's
right cheek bone. One contends the marks resulted from stone tools wielded by
hominin relatives and the other asserts that they were formed through contact
with sharp-edged stone blocks found lying against the skull. Further, even if
ancient hominins produced the marks, it is not clear whether they were
butchering each other for food, given the lack of large muscle groups on the
skull.
To resolve the issue of
whether the fossil tibia she and her colleagues studied is indeed the oldest
cut-marked hominin fossil, Pobiner said she would love to reexamine the skull
from South Africa, which is claimed to have cut marks using the same techniques
observed in the present study.She also said this new shocking finding is proof
of the value of museum collections."You can make some pretty amazing
discoveries by going back into museum collections and taking a second look at
fossils," Pobiner said. "Not everyone sees everything the first time
around. It takes a community of scientists coming in with different questions
and techniques to keep expanding our knowledge of the world."
4) Researchers
uncover new CRISPR-like system in animals that can edit the human genome by
Broad Institute of MIT and Harvard:
A Cryo-EM map of a Fanzor protein (gray, yellow, light blue, and pink) in complex with ωRNA (purple) and its target DNA (red). Non-target DNA strand in blue. |
A team of researchers
led by Feng Zhang at the Broad Institute of MIT and Harvard and the McGovern
Institute for Brain Research at MIT has uncovered the first programmable
RNA-guided system in eukaryotes—organisms that include fungi, plants, and
animals.
In a study published in
Nature, the team describes how the system is based on a protein called Fanzor.
They showed that Fanzor proteins use RNA as a guide to target DNA precisely,
and that Fanzors can be reprogrammed to edit the genome of human cells. The
compact Fanzor systems have the potential to be more easily delivered to cells
and tissues as therapeutics than CRISPR/Cas systems, and further refinements to
improve their targeting efficiency could make them a valuable new technology
for human genome editing.
CRISPR/Cas was first
discovered in prokaryotes (bacteria and other single-cell organisms that lack
nuclei) and scientists including Zhang's lab have long wondered whether similar
systems exist in eukaryotes. The new study demonstrates that RNA-guided
DNA-cutting mechanisms are present across all kingdoms of life.
"CRISPR-based systems are widely used and powerful because they can be easily
reprogrammed to target different sites in the genome," said Zhang, senior
author on the study and a core institute member at the Broad, an investigator
at MIT's McGovern Institute, the James and Patricia Poitras Professor of
Neuroscience at MIT, and a Howard Hughes Medical Institute investigator.
"This new system is another way to make precise changes in human cells,
complementing the genome editing tools we already have."
McGovern Investigator Feng Zhang in his lab. |
Searching the
domains of life
A major aim of the Zhang
lab is to develop genetic medicines using systems that can modulate human cells
by targeting specific genes and processes. "A number of years ago, we
started to ask, 'What is there beyond CRISPR, and are there other
RNA-programmable systems out there in nature?'" said Zhang.
Two years ago, Zhang lab
members discovered a class of RNA-programmable systems in prokaryotes called
OMEGAs, which are often linked with transposable elements, or "jumping
genes," in bacterial genomes and likely gave rise to CRISPR/Cas systems.
That work also highlighted similarities between prokaryotic OMEGA systems and
Fanzor proteins in eukaryotes, suggesting that the Fanzor enzymes might also
use an RNA-guided mechanism to target and cut DNA. In the new study, the
researchers continued their study of RNA-guided systems by isolating Fanzors
from fungi, algae, and amoeba species, in addition to a clam known as the
Northern Quahog. Co-first author Makoto Saito of the Zhang lab led the
biochemical characterization of the Fanzor proteins, showing that they are
DNA-cutting endonuclease enzymes that use nearby non-coding RNAs known as ωRNAs
to target particular sites in the genome. It is the first time this mechanism
has been found in eukaryotes, such as animals.
Unlike CRISPR proteins,
Fanzor enzymes are encoded in the eukaryotic genome within transposable
elements and the team's phylogenetic analysis suggests that the Fanzor genes
have migrated from bacteria to eukaryotes through so-called horizontal gene
transfer.
"These OMEGA
systems are more ancestral to CRISPR and they are among the most abundant
proteins on the planet, so it makes sense that they have been able to hop back
and forth between prokaryotes and eukaryotes," said Saito.To explore
Fanzor's potential as a genome editing tool, the researchers demonstrated that
it can generate insertions and deletions at targeted genome sites within human
cells. The researchers
found the Fanzor system to initially be less efficient at snipping DNA than
CRISPR/Cas systems, but by systematic engineering, they introduced a
combination of mutations into the protein that increased its activity 10-fold.
Additionally, unlike some CRISPR systems and the OMEGA protein TnpB, the team
found that a fungal-derived Fanzor protein did not exhibit "collateral
activity," where an RNA-guided enzyme cleaves its DNA target as well as
degrading nearby DNA or RNA. The results suggest that Fanzors could potentially
be developed as efficient genome editors.
Co-first author
Peiyu Xu led an effort to analyze the molecular structure of the Fanzor/ωRNA
complex and illustrate how it latches onto DNA to cut it. Fanzor shares
structural similarities with its prokaryotic counterpart CRISPR-Cas12 protein,
but the interaction between the ωRNA and the catalytic domains of Fanzor is
more extensive, suggesting that the ωRNA might play a role in the catalytic
reactions. "We are excited about these structural insights for helping us
further engineer and optimize Fanzor for improved efficiency and precision as a
genome editor," said Xu.
Like
CRISPR-based systems, the Fanzor system can be easily reprogrammed to target
specific genome sites, and Zhang said it could one day be developed into a
powerful new genome editing technology for research and therapeutic applications.
The abundance of RNA-guided endonucleases like Fanzors further expands the
number of OMEGA systems known across kingdoms of life and suggests that there
are more yet to be found."Nature is amazing. There's so much
diversity," said Zhang. "There are probably more RNA-programmable
systems out there, and we're continuing to explore and will hopefully discover
more."
5) New mass
spectrometry combo offers promise for tapping nature's unknown chemical
universe by Tom Rickey, Pacific Northwest National Laboratory:
A SLIM approach Ion mobility spectrometry brings hefty results |
The universe is awash in
billions of possible chemicals. But even with a bevy of high-tech instruments,
scientists have determined the chemical structures of just a small fraction of
those compounds, maybe 1%.
Scientists at the
Department of Energy's Pacific Northwest National Laboratory (PNNL) are taking
aim at the other 99%, creating new ways to learn more about a vast sea of
unknown compounds. There may be cures for disease, new approaches for tackling
climate change, or new chemical or biological threats lurking in the chemical
universe.The work is part of an initiative known as m/q, or "m over
q"—shorthand for mass divided by charge, which signifies one of the ways
that scientists measure chemical properties in the world of mass spectrometry."Right
now, we can take a sample from soil, where, depending on soil type, there may
be thousands of chemical compounds in just a teaspoon's worth," said
Thomas Metz, who leads the m/q Initiative. "And we don't know what most of
them are in terms of their chemical structures. We simply have no idea what's
in there."
Chemist Chelsea Hutchinson prepares samples for a run on a mass spectrometer |
Scientists typically
rely on reference libraries that contain information about thousands of
molecules to identify substances. Researchers sort their samples from soil, the
body, or elsewhere and compare what they have measured experimentally to what's
in the library. While that's helpful, it limits scientists to only structurally
identifying molecules that have been seen before—for example, through analysis
of standard compounds purchased from chemical suppliers.In the latest
development, a team led by scientist Adam Hollerbach has combined two
high-resolution instruments into one system to size up molecules in
unprecedented detail. The results were published June 12 in the journal
Analytical Chemistry.Now, scientists can make several important measurements
about chemical compounds in one experiment, gaining important information
faster, more conveniently, and more accurately than before.
Hollerbach's technique
applies to ions—molecules that have either a positive or negative charge. That
makes them easier to control and possible to detect using mass spectrometry.
Scientists typically
rely on reference libraries that contain information about thousands of
molecules to identify substances. Researchers sort their samples from soil, the
body, or elsewhere and compare what they have measured experimentally to what's
in the library. While that's helpful, it limits scientists to only structurally
identifying molecules that have been seen before—for example, through analysis
of standard compounds purchased from chemical suppliers.In the latest
development, a team led by scientist Adam Hollerbach has combined two
high-resolution instruments into one system to size up molecules in
unprecedented detail. The results were published June 12 in the journal
Analytical Chemistry.Now, scientists can make several important measurements
about chemical compounds in one experiment, gaining important information
faster, more conveniently, and more accurately than before.Hollerbach's
technique applies to ions—molecules that have either a positive or negative
charge. That makes them easier to control and possible to detect using mass
spectrometry.
Mass spectrometry:
Tool of the ion whisperers
SLIM, an ion mobility spectrometer, is a 42-foot-long molecular racetrack packed into a small area around which ions race—yielding insights into their chemical structure |
Like the people who
study them, ions have many features that distinguish one from another. In
people, weight, hair color, size, shape, eye color, and many other
characteristics help us know who's who. For ions, identifying characteristics
include mass, shape, size, electric charge, and chemical composition. Those not
only serve as identifiers but also as guides to the associated molecules'
behavior—clues to their potential to cure disease or sop up pollutants, for
example.That understanding should help the efforts of scores of scientists at
PNNL who focus on understanding the effect of microbes on climate. Microbes
play a key role in transforming elements like carbon into other forms that are
important for the planet. Their impact on warming or cooling the planet is
mighty. But scientists have much to learn.
"There may be
millions of microbes in just a gram of soil, and we don't know who most of them
are or what they do. There's a lot of discovery still to happen," said
Metz. "From the viewpoint of challenging science, it's either a worst-case
scenario or one of our greatest opportunities, depending on how you look at
it."The m/q scientists are seizing the opportunity. Instead of framing
their questions within the relatively small number of compounds that can be
identified in conventional mass spectrometry measurements, they're trying to
leapfrog current limitations and create a whole new way of identifying what is
unknown today. It's a bit like when a new telescope is deployed and reveals
several distinct stars where before, just one blurry hodgepodge of celestial
bodies was visible.The work is both experimental, putting molecules through
their paces in the laboratory, and on computers, where scientists model what
they are seeing and predict what they will likely see.In the experiments described
in the Analytical Chemistry paper, Hollerbach and colleagues made sensitive
measurements of peptides and lipids. The experiments combined two instruments
with similar names but that provide different details about ions. Both are used
in mass spectrometry, a field whose history is interwoven with discoveries by
PNNL scientists.
Researcher Jason Toyoda prepares samples for mass spectrometry experiments |
The first instrument is
a mass spectrometer, which measures an ion's mass, electric charge, and how the
ion breaks apart. In this study, the team used an Orbitrap developed by Thermo-Fisher
Scientific. Such instruments sort molecules of different masses well, but two
molecules with the same mass are difficult to separate. Think of two people,
each weighing 180 lbs.—one is tall and thin while the other is short and
stocky. On a scale alone, they would be impossible to separate.
A SLIM approach:
Ion mobility spectrometry brings hefty results
The second instrument is
known as SLIM: structures for lossless ion manipulations. SLIM, created by PNNL
scientist Richard D. Smith and colleagues, is an ion mobility spectrometer that
measures an ion's size and electric charge.
SLIM, which is about the
size of a laptop and stands at just one-quarter of an inch thick, is a hothouse
of molecular activity. Dozens of long, winding paths transform the small device
into a 42-foot-long molecular racetrack, with ions that are controlled tightly
by electric fields racing round and round an oval obstacle course.
The
"obstacles" are other, known molecules such as helium or nitrogen
molecules. As the ions under study race through the SLIM device, they navigate
around or through the other molecules, tumbling and swerving much like a
football running back runs through and around opposing blockers. The term
"ion mobility spectrometry" truly captures the action.
By recording how long it
takes for the ions to complete the course—how deftly they navigate the blocking
ions—scientists learn all kinds of things about ions' shape and size. That
information, which isn't available from a standard mass spec instrument, is combined
with data about the ion's mass, electric charge, and fragmentation pattern.
Altogether, the data yields the ion's collision cross section, its molecular
formula, and its fragmentation pattern, properties that are central to
understanding a molecule's structure.
Scientists in the mq Initiative are developing new ways to identify compounds in the vast unknown chemical universe |
"Two different
molecules can have the same number of atoms, and the same mass and charge, but
they could have very different structures and activity. That's where SLIM comes
in to tell the difference," said Hollerbach. "Just one small change
can mean the difference between a molecule that is indicative of a disease and
one that's not."
The key to Hollerbach's
experiment was getting the two different instruments to play nicely together.
While both standard mass spectrometry and ion mobility spectrometry analyze
ions, they work on different time scales. Ions make their journey through SLIM
and arrive at the Orbitrap faster than they can be processed.So Hollerbach drew
on an old technique, deploying "dual-gated ion injection." He added
gates to control the intake of ions into the system and to control their
arrival at the Orbitrap, choosing to send some of the ions from SLIM into
oblivion to keep the flow at a manageable rate."Really, the questions we
ask are very simple," said Hollerbach. "What is this, and how much is
there? But the techniques we use are complex."Other m/q scientists are
working on additional ways to identify or exploit unknown molecules. Some are
creating ways to use data like that from Hollerbach's experiment to predict an
ion's structure automatically, so drug makers and other scientists would know
exactly what they're working with. Others are scouting out the millions of
possibilities for forms of compounds such as fentanyl, sorting out what's
unlikely from what might show up on the street one day. Then they predict how
those compounds would behave inside a mass spectrometer—creating a way to
identify them if and when they do show up.
6) Researchers make
a quantum computing leap with a magnetic twist by James Urton, University of Washington:
This artistic depiction shows electron fractionalization in which strongly interacting charges can fractionalize into three parts in the fractional quantum anomalous Hall phase |
Quantum computing could
revolutionize our world. For specific and crucial tasks, it promises to be
exponentially faster than the zero-or-one binary technology that underlies
today's machines, from supercomputers in laboratories to smartphones in our
pockets. But developing quantum computers hinges on building a stable network
of qubits—or quantum bits—to store information, access it and perform
computations.
Yet the qubit platforms
unveiled to date have a common problem: They tend to be delicate and vulnerable
to outside disturbances. Even a stray photon can cause trouble. Developing
fault-tolerant qubits—which would be immune to external perturbations—could be
the ultimate solution to this challenge.
A team led by scientists
and engineers at the University of Washington has announced a significant
advancement in this quest. In a pair of papers published June 14 in Nature and
June 22 in Science, the researchers report that in experiments with flakes of
semiconductor materials—each only a single layer of atoms thick—they detected
signatures of "fractional quantum anomalous Hall" (FQAH) states.
The team's discoveries
mark a first and promising step in constructing a type of fault-tolerant qubit
because FQAH states can host anyons—strange "quasiparticles" that
have only a fraction of an electron's charge. Some types of anyons can be used
to make what are called "topologically protected" qubits, which are
stable against any small, local disturbances."This really establishes a
new paradigm for studying quantum physics with fractional excitations in the
future," said Xiaodong Xu, the lead researcher behind these discoveries,
who is also the Boeing Distinguished Professor of Physics and a professor of
materials science and engineering at the UW.
FQAH states are related
to the fractional quantum Hall state, an exotic phase of matter that exists in
two-dimensional systems. In these states, electrical conductivity is
constrained to precise fractions of a constant known as the conductance
quantum. But fractional quantum Hall systems typically require massive magnetic
fields to keep them stable, making them impractical for applications in quantum
computing. The FQAH state has no such requirement—it is stable even "at
zero magnetic field," according to the team. Hosting such an exotic phase
of matter required the researchers to build an artificial lattice with exotic
properties. They stacked two atomically thin flakes of the semiconductor
material molybdenum ditelluride (MoTe2) at small, mutual "twist" angles
relative to one another. This configuration formed a synthetic "honeycomb
lattice" for electrons.
When researchers cooled
the stacked slices to a few degrees above absolute zero, an intrinsic magnetism
arose in the system. The intrinsic magnetism takes the place of the strong
magnetic field typically required for the fractional quantum Hall state. Using
lasers as probes, the researchers detected signatures of the FQAH effect, a
major step forward in unlocking the power of anyons for quantum computing.
The team—which also
includes scientists at the University of Hong Kong, the National Institute for
Materials Science in Japan, Boston College and the Massachusetts Institute of
Technology—envisions their system as a powerful platform to develop a deeper
understanding of anyons, which have very different properties from everyday
particles like electrons.
Anyons are
quasiparticles—or particle-like "excitations"—that can act as
fractions of an electron. In future work with their experimental system, the
researchers hope to discover an even more exotic version of this type of
quasiparticle: "non-Abelian" anyons, which could be used as
topological qubits. Wrapping—or "braiding"—the non-Abelian anyons
around each other can generate an entangled quantum state. In this quantum
state, information is essentially "spread out" over the entire system
and resistant to local disturbances—forming the basis of topological qubits and
a major advancement over the capabilities of current quantum computers.
"This type of
topological qubit would be fundamentally different from those that can be
created now," said UW physics doctoral student Eric Anderson, who is lead
author of the Science paper and co-lead author of the Nature paper. "The
strange behavior of non-Abelian anyons would make them much more robust as a
quantum computing platform."
Three key properties,
all of which existed simultaneously in the researchers' experimental setup,
allowed FQAH states to emerge:
Magnetism: Though MoTe2
is not a magnetic material, when they loaded the system with positive charges,
a "spontaneous spin order"—a form of magnetism called ferromagnetism—emerged.
Topology: Electrical
charges within their system have "twisted bands," similar to a Möbius
strip, which helps make the system topological.
Interactions: The
charges within their experimental system interact strongly enough to stabilize
the FQAH state.
The team hopes that
non-Abelian anyons await discovery via this new approach.
"The observed
signatures of the fractional quantum anomalous Hall effect are inspiring,"
said UW physics doctoral student Jiaqi Cai, co-lead author on the Nature paper
and co-author of the Science paper. "The fruitful quantum states in the
system can be a laboratory-on-a-chip for discovering new physics in two
dimensions, and also new devices for quantum applications."
"Our work provides
clear evidence of the long-sought FQAH states," said Xu, who is also a
member of the Molecular Engineering and Sciences Institute, the Institute for
Nano-Engineered Systems and the Clean Energy Institute, all at UW. "We are
currently working on electrical transport measurements, which could provide
direct and unambiguous evidence of fractional excitations at zero magnetic
field."
The team believes that
with their approach, investigating and manipulating these unusual FQAH states
can become commonplace—accelerating the quantum computing journey.
7) New venom
discovery from deadly cone snails by University of Queensland:
Adult Conus magus cone snail eating fish |
University of Queensland researchers have reared deadly cone snails in a laboratory aquarium for the first time, uncovering a potential treasure trove of new venoms for drug development. The findings are published in the journal Nature Communications.
Professor Richard Lewis,
Dr. Aymeric Rogalski and Dr. Himaya Siddhihalu Wickrama Hewage from UQ's
Institute for Molecular Bioscience study venoms as therapeutics, and discovered
crucial differences across the lifecycle of the tiny carnivorous marine
species.
Professor Lewis said
they found variations in the Conus magus diet, behavior and toxicity.
"Juvenile cone snails use a different cocktail of venoms than adult snails
to kill their prey," Professor Lewis said.
Juvenile cone snails under a microscope |
"This is a rich and
unexplored group of molecules that we can now examine as potential leads for
drugs.
"A lot of our
success with venom molecules has been in developing pain medications, but
depending on the pharmacology we'll see if it has therapeutic potential for any
of the disease classes."The researchers were also surprised to find
juvenile cone snails didn't feed on fish like the adults of the
species."The juveniles would only eat polychaete worms, which they catch using
a specific hunting technique we named 'sting and stalk,'" Professor Lewis
said."They jab the worm with a harpoon-like structure before injecting it
with venom to subdue it."The juvenile snail then slowly stalks the worm
and sucks it up, like a small piece of spaghetti."During the larvae stage,
cone snails feed on a type of microalgae, with their diet changing after their
metamorphosis into half-millimeter-long juveniles.
Professor Lewis said
researchers around the world have studied adult marine cone snails and their
deadly venom, but little had been known about their early life stages.
"This is because
their eggs, larvae and juveniles are so hard to find and difficult to rear in
an aquarium," he said."Dr. Rogalski took up the challenge during his
Ph.D., establishing very elaborate aquaculture studies to find out how and what
each stage of the snail ate."The researchers now have a sustainable system
in which they can rear cone snails in a controlled environment, enabling
studies of the life cycle and venoms of the juveniles.
1) Rahul Gandhi:
Congress leader meets victims of violence in Manipur:By Cherylann Mollan BBC
News, Mumbai:
India's opposition
leader Rahul Gandhi has met people affected by the violence that has engulfed
the north-eastern state of Manipur.On Friday, the Congress leader visited
relief camps in Moirang town and met displaced families, the party said.
Mr Gandhi, who is on a
two-day trip to the state, also visited a relief camp in Churachandpur district
on Thursday.He travelled there by helicopter after his convoy was stopped by
the police, who cited security concerns.
Mr Gandhi is scheduled
to meet leaders of civil society groups on Friday in the state capital,
Imphal.For the past two months, Manipur has been convulsed by clashes between
the majority Meitei and Kuki communities.More than 100 people have been killed
and 400 wounded in the violence. Tens of thousands have fled their
homes.Clashes broke out after the state's main ethnic group, the Meiteis,
demanded tribal status which gives access to benefits such as forest land and
government job and education quotas.
Prime Minister Narendra
Modi has met top government officials to review the situation in Manipur but he
has been criticised for not visiting the state or commenting on the situation
there.Almost a month after violence began, Home Minister Amit Shah visited the
state to put in place a plan to restore normalcy, but fresh incidents of
violence continue to be reported almost daily.After arriving in Imphal on
Thursday morning, Mr Gandhi shared a Facebook post saying that
"restoration of peace is the top priority. Manipur needs healing, and only
together we can bring harmony".
But soon after, senior
Congress leader KC Venugopal told reporters that Mr Gandhi's convoy had been
stopped by police near Bishnupur district while he was on his way to
Churachandpur town to visit relief camps."Police say that they are not in
a position to allow us. People are standing on both sides of the road to wave
to Rahul Gandhi. We are not able to understand why have they stopped us?"
Mr Venugopal said.
Police said the convoy
had been stopped for Mr Gandhi's security. "Seeing the ground situation,
we stopped him from moving forward and advised him to travel to Churachandpur
via a helicopter," Heisnam Balram Singh, a senior Bishnupur police
official, told ANI news agency. Congress Party president Mallikarjun Kharge
accused the Bharatiya Janata Party (BJP) government of "using autocratic
methods to stall a compassionate outreach" by Mr Gandhi.
"This is totally
unacceptable and shatters all Constitutional and Democratic norms. Manipur
needs peace, not confrontation," he tweeted.Congress MP Jairam Ramesh said
Mr Gandhi's two-day visit to the state was in the spirit of his Bharat Jodo
Yatra - a five-month long unity march across the country."The Prime
Minister may choose to remain silent or be inactive but why stop Rahul Gandhi's
efforts to listen to all sections of the Manipuri society and provide a healing
touch?" he said.
However, some BJP
leaders have criticised the timing of Mr Gandhi's visit, calling it politically
motivated.Nearly 60,000 people have been displaced due to violence in Manipur
and are taking shelter in some 350 camps.
Mr Gandhi's visit comes
amid the opposition's demand for the resignation of the state's chief minister,
N Biren Singh, who is from the BJP.Congress leaders have criticised Mr Singh
for not being able to "restore peace and normalcy" in the state and
have asked for federal rule to be imposed. Mr Venugopal tweeted about Mr
Gandhi's visit on Tuesday, and said that the state had been "burning for
nearly two months" and "desperately needs a healing touch so that
society can move from conflict to peace".
Since the clashes began
early in May, many homes, churches and temples have been destroyed by mobs
while the homes of some state ministers and legislators have been attacked and
set on fire.Close to 40,000 security forces have been deployed to quell the
violence.But the situation continues to remain tense. Normal life has been
thrown completely out of gear for the locals who are facing curfews, internet
shutdowns and sporadic killings and arson.
2) Chandra Shekhar
Aazad Attack: Wrestlers Meet Bhim Army Chief in Hospital:
Aazad is alright and has
been taken to CHC for medical treatment, said SSP Vipin TadaWrestlers Sakshi
Malik and Bajrang Punia visited Aazad Samaj Party (Kanshi Ram) chief Chandra
Shekhar Aazad in the hospital, a day after his convoy was attacked by armed men
in Saharanpur, Uttar Pradesh.
A First Information
Report (FIR) was also registered over the attack on Thursday, 29 June.
"Half an hour back,
the convoy of Chandra Shekhar Aazad was fired at by a few car-borne armed men.
A bullet brushed past him. He is alright and has been taken to CHC for medical
treatment. Police is investigating the matter," said SSP Vipin Tada said
on Wednesday, 28 June. "I don't remember who they were, my associates identified
them. The car ran ahead of us towards Saharanpur. Ours was the only car at that
point, the other cars of the convoy were either ahead or behind us. My younger
brother Manish was among the five people in the car. We took a U-turn after the
attack. I called SSP Saharanpur and told him that I am hurt, that's all I
remember. Can't point out to anybody I know as a suspect," Aazad had said.
The case has been registered under charges of attempt to murder and provisions
of offences under the Scheduled Castes
and the Scheduled Tribes (SC/ST) Act.
Meanwhile, the Haryana
registered Maruti Suzuki Swift Dzire car used by the shooters in the attack on
Azad samaj party chief Chandrashekhar Azad has been recovered by the police,
Ajay Sahni, Deputy Inspector General, Saharanpur range told The Quint.
"It was found
abandoned at an undisclosed location in Deoband, Saharanpur. It is learnt from
the police sources that the shooters fled after abandonding the vehicle.
Efforts are being made to ascertain the identity of the shooters," Sahni
said.
'Opposition a Target
in UP': SP
Reacting to the
incident, for UP Chief Minister Akhilesh Yadav said, "The attack on
Chandra Shekhar Aazad, National President of Aazad Samaj Party in Deoband,
Saharanpur, by criminals protected by the government is highly condemnable and
cowardly act. When the people's representatives are not safe in the BJP rule,
then what will happen to the general public? Jungle Raj in UP!"
Meanwhile, SP leader
Shivpal Yadav said, "The morale of the criminals in the state is so high
that the chaotic elements have started breaking all their limits and
boundaries. The opposition in UP is now the target of both the government and
the criminals. The deadly attack on Bhim Army Chief Chandra Shekhar Aazad is an
alarm for the hollow law and order situation in the state."
3) 'Will Not Be
Stepping Down as Chief Minister of Manipur', Biren Singh Clarifies:
N Biren Singh had
convened a meeting of Cabinet ministers at 8 am in which he announced his
decision to quit as CM. Amid intense speculation, N Biren Singh clarified on
Twitter on Friday, 30 June, that he will not be stepping down as the Chief
Minister of Manipur. "At this critical juncture, I wish to clarify that I
will not be resigning from the post of Chief Minister," Singh said on Twitter.
Earlier, senior minister
Govindas Konthoujam said while addressing a group of people that the chief
minister has decided not to resign, respecting the sentiments of the people and
a large crowd that had blocked his convoy when he was on the way to the Raj
Bhawan on Friday.The crowd, which included a large number of women, tore apart
the resignation letter which Biren Singh was carrying to Raj Bhawan at around
2:30 pm, according to Deccan Herald.The crowd had gathered in front of the CM's
official residence in Imphal and had blocked the convoy in which he was
travelling to meet the Governor.
The protesting women
emphasised the need for stability and continuity in leadership, particularly at
a time when social and political tensions are high.
Singh's resignation,
they argued, could exacerbate the existing unrest and hinder progress towards
finding a peaceful resolution to the state's issues.Sarojini, a protester,
said, "Now the Chief Minister and his Cabinet ministers are about to
resign but they can’t do this at this juncture. We have chosen them as our
leaders; so they can’t resign without our permission."
Earlier, Singh had
convened a meeting of Cabinet ministers at his residence at around 8 am, in
which he announced his decision to quit, according to Deccan
Herald.Speculations of Singh's resignation were triggered on Friday, 30 June,
after almost two months of his reported failure to stop the violence in the
state. Singh had also met Home Minister Amit Shah in Delhi on 25 June.
According to a report published
in Manipur daily Sangai Express, Singh received several calls from New Delhi on
Thursday, 29 June, in which he was offered the option to put in his papers or
the Centre would "take over the administration."
The Assembly is likely
to be put in put in animated suspension, the report added.Singh has been facing
flak from Opposition parties as well as his own party for the way he has been
handling the crisis in the hill state.The violence has left more than 100
people dead, over 300 people injured, and thousands displaced.
4) PM Modi ‘uneasy’
as Opposition plans next meet in Bengaluru on July 13, 14, says Sharad Pawar:
Bengaluru meet to
discuss future electoral strategy, ways to combat BJP’s misuse of power and
creation of communal situations; focus on women’s reservation before talking of
UCC, says NCP chief.
Remarking that Prime
Minister Narendra Modi’s “uneasiness” had increased following the June 23
meeting of Opposition parties in Patna, Nationalist Congress Party (NCP)
president Sharad Pawar on June 29 said that the next meeting of Opposition
parties would be held in Bengaluru on July 13 and 14.
“It appears that the
PM’s uneasiness has increased after our Patna meeting where leaders of 16
Opposition parties gathered. He was in America when we met in Patna… On his
return, when he came to know of our meeting, his uneasiness started increasing
and he began attacking us at a personal level. He even called our meeting ‘a
photogenic session’. We have taken a decision to meet again on July 13 and 14
in Bengaluru,” Mr. Pawar said, adding that a previous plan to hold the meeting
in Shimla had been scrapped as the hill-station was facing excess rainfall.
5) Congress
questions high cost of US drone deal; corruption in Opp party’s DNA, says BJP:
The BJP reacted sharply
to the Congress stand on the deal saying that “doing scams in defence deals has
become a part of the opposition party's DNA and it cannot see beyond
corruption”. The Congress on Wednesday raised questions on the multi-crore
India-US drone deal, alleging that the government is procuring 31 MQ-9B
Predator UAV drones for a higher price and demanded complete transparency
regarding the contract. The main opposition party claimed that several countries
have brought MQ-9B Predator Drones or very similar variants at a lower price
than India.
The BJP reacted sharply
to the Congress stand on the deal saying that “doing scams in defence deals has
become a part of the opposition party’s DNA and it cannot see beyond
corruption”.
Addressing a press
conference at the AICC headquarters, Congress media department head Pawan Khera
claimed that the US Air Force bought MQ-9 drone, which is a superior quality
version, at USD 56.5 million per drone while the UK Air Force bought MQ-9B
drone at USD 12.5 million per drone in 2016.
Demanding "complete
transparency" in the Predator drone deal, the Congress on Wednesday
alleged that the Narendra Modi government was buying 31 drones by paying four
times more than what other countries paid. Congress Media Department Chairman
Pawan...
Earlier on Sunday, the
Ministry of Defence said that it is yet to finalise the cost and specific terms
of purchase of 31 drones from the United States and it will examine the price
offered to other nations before concluding the procurement.
The Congress alleged that the Government of
India is paying 3.072 billion (Rs 25,200 crore) deal for 31 MQ-9B Predator
drones manufactured by General Atomics. "Why is India paying more than the
actual price for a drone, as compared to other countries? Why are we paying the
highest price for a drone, which does not have AI integration," Congress
asked.
6) Bengal BJP
questions timing of Mamata Banerjee's injury ahead of panchayat polls:
Bengal BJP chief Sukanta
Majumdar wished Chief Minister Mamata Banerjee a speedy recovery while
questioning the timing of her injury ahead of panchayat elections in the state.
The state BJP questioned how Mamata Banerjee gets injured in a specific area
every time an election is near.
The Trinamool Congress
chief was injured today when the helicopter she was flying in made an emergency
landing at the Sevoke air base near Siliguri due to inclement weather.
Mamata to campaign
for panchayat elections, Opp says she is feeling the heat
West Bengal Chief
Minister Mamata Banerjee will commence her campaign for the ensuing panchayat
elections in the state on Monday from Cooch Behar district. The Trinamool
Congress chief reached Cooch Behar on Sunday afternoon and will address a
public meeting at Cooch Behar in north Bengal on Monday, commencing her
campaign for the panchayat polls, party leaders said.
The BJP alleged that
doubts over the outcome of the rural polls have forced the TMC chief to canvass
for party candidates in the panchayat polls. BJP national vice president Dilip
Ghosh said it is below her political stature to campaign for the rural polls.
“When her party leaders claim that she is a potential prime ministerial
candidate, it is expected that she campaigns for the Lok Sabha and the assembly
elections; it seems she is worried about the outcome of the polls,” Ghosh told
reporters here.
Mamata Banerjee
turns ‘tea-seller’ while campaigning for Bengal panchayat polls.
As panchayat poll
fervour heats up in West Bengal, chief minister Mamata Banerjee amped up her
election campaign by serving tea to people in Jalpaiguri's Malbazar. In a video
shared by news agency ANI, Banerjee was seen making tea at a roadside stall.
The CM on Monday accused
the BSF of threatening voters at the orders of the BJP and asked the police to
keep a close tab on their activities.
Banerjee assured that
the party will strive to remove corruption in the local body as the party had
renewed its focus to the rural polls through mass outreach programmes. She
added that people's views were considered while choosing candidates Taking a
dig at BJP's "double engine government" slogan, the TMC supremo said
it would be trounced in the panchayat and 2024 Lok Sabha polls. "We will
oust the BJP from the Centre and bring a development-oriented government in the
country," she added.
The state has been
witnessing political clashes ever since the announcement of the July 8
elections.
The Calcutta high court
had earlier ordered the deployment of central paramilitary forces in seven sensitive
districts to ensure peaceful polls. The Supreme Court on Tuesday approved the
same and dismissed the petitions filed by the state government and the state
election commission (SEC) against the HC order in this.
Around 5.67 crore voters
are set to vote to elect nearly 75,000 candidates in zilla parishads, panchayat
samiti and gram panchayats.
5 aboard Titanic
tourist sub are dead after ‘catastrophic implosion’ BY ALEXANDRA E. PETRISTAFF
WRITER JUNE 22, 2023 UPDATED 5:17 PM PT:
All five passengers aboard
a submersible that vanished while on a dive to explore the Titanic wreck site
have died, officials said Thursday after underwater robots discovered seafloor
debris from the sub that was “consistent with a catastrophic implosion.”
A robot from the Canadian
vessel Horizon Arctic discovered several major pieces of the 21-foot sub, the
Titan, in a debris field about 1,600 feet from the bow of the Titanic, U.S.
Coast Guard Rear Adm. John W. Mauger said at a news conference.
“The debris is
consistent with the catastrophic loss of the pressure chamber,” Mauger said.
The families of the
passengers have been notified, he said.
“On behalf of the U.S.
Coast Guard and the entire unified command, I offer my deepest condolences to
the families,” he said. “I can only imagine what this has been like for them. I
hope that this discovery provides some solace during this difficult time.”
The five passengers were
Stockton Rush, the pilot of the exploration and chief executive of OceanGate
Expeditions, which owns and operates the sub; Hamish Harding, chairman of
Action Aviation, a Dubai-based aircraft dealer; Paul-Henry Nargeolet, a veteran
and accomplished diver with more than 30 trips to the wreck site; and Pakistani
businessman Shahzada Dawood and son Suleman. OceanGate said in a statement that
its “hearts are with these five souls and every member of their families during
this tragic time.”
“These men were true
explorers who shared a distinct spirit of adventure and a deep passion for
exploring and protecting the world’s ocean,” the company said. “We grieve the
loss of life and joy they brought to everyone they knew.” The sub was reported
missing after it lost contact with the Canadian research vessel Polar Prince
about 1 hour and 45 minutes into its dive Sunday about 900 miles east of Cape
Cod, Mass., the Coast Guard said.Its disappearance set off an international
search-and-rescue effort, as crews raced around the clock using specialized
equipment to find the sub, which was designed to have an initial air supply of
96 hours. Officials also said it had only “limited rations” of food and
water.The search grew to 10,000 square miles, roughly the size of
Massachusetts, and went 2½ miles deep. Through the days-long effort, officials
maintained optimism that the operation would remain a search-and-rescue effort
and not a recovery mission.
Assets launched in the
search included American and Canadian aerial support vessels that scanned the
ocean’s surface and subsurface using sonobuoys; U.S. Navy divers; coast guard
and research vessels from Canada, France and Norway, some of which were
equipped with highly specialized remote-operated vehicles that could work on
the ocean’s floor; and assistance from commercial vessels.
A moment of promise came
Tuesday when the Coast Guard confirmed reports that banging noises were
detected on the seafloor by sonobuoys dropped from Canadian aircraft. Although
officials said the origins of the sounds were unclear, they became the target
of search efforts. At the news conference Thursday, Mauger said the underwater
noises, which were also observed Wednesday, did not appear to be connected to
the sub’s location. The implosion would generate “significant broadband sound”
that would have been picked up by the sonobuoys, he said.
Paul Hankins, a salvage
expert for the U.S. Navy, said five major pieces of debris from the Titan were
found, including the nose cone, which was outside of the pressure hull. Crews
also found a large debris field that contained the front-end bell of the
pressure hull.
“That was the first
indication there was a catastrophic event,” he said. A second, smaller debris
field contained the other end of the pressure hull and other wreckage that
compromised the totality of the vessel.
Officials said that the
debris was in an area away from the Titanic wreckage in a patch of smooth ocean
floor and that there were no signs the vessel collided with the historic ship.
The size of the debris field and the vessel’s last-known location are
consistent with an “implosion in the water column,” officials said.
Mauger said it is too
early to tell when the vessel imploded, and added that listening equipment used
throughout the search did not detect any type of catastrophic event.
However, a U.S.
government official familiar with the incident but not authorized to speak to
the media told The Times that technology designed to listen to the ocean for
movement captured the sound of the submersible imploding around the time
communications were lost. The news was first reported by the Wall Street Journal,
which noted the sound “anomaly.”
When asked whether the
victims’ remains might be recovered, Mauger said he did not have an answer,
reiterating the implosion and underlining the ocean’s harsh conditions. “This
is an incredibly unforgiving environment down there on the seafloor,” he said.
Like the
search-and-rescue efforts, the investigation into what happened will be
complex, Mauger said, because of the remote location where the event occurred
and because it involves the government agencies of several countries whose
citizens were aboard.
The composite material
used to build the sub and a lack of safety systems will be the focus of a
maritime inquiry, which most likely will involve Canadian and U.S.
investigators, according to sources familiar with such operations.
Nine vessels were at the
location Thursday, and demobilization efforts are expected to take place over
the next 24 hours. But remote-operated vehicles will continue to map the ocean
floor, Mauger said, and officials are working to develop a timeline of the
implosion.
“I know that there’s
also a lot of questions about how, why and when did this happen,” Mauger said.
“Those are questions that we will collect as much information as we can on
now.” OceanGate has been running expeditions with “citizen explorers” to the
Titanic since 2021 on its Titan sub, according to its website. But as the
search unfolded, new details emerged that submersible industry leaders,
oceanographers and former employees had long sent warning signs about the
Titan.
The Manned Underwater
Vehicles Committee at the Marine Technology Society, which advocates for marine
technology and resources, wrote a private letter to Rush in 2018 calling on him
to allow for a third-party safety review of the Titan. The letter said the
marketing for the Titan was, “at minimum, misleading to the public and breaches
an industry-wide professional code of conduct we all endeavor to uphold.”
“Our apprehension is
that the current experimental approach adopted by OceanGate could result in
negative outcomes (from minor to catastrophic) that would have serious
consequences for everyone in the industry,” the letter stated.
That same year, David
Lochridge, a former OceanGate employee, raised red flags about the Titan in
litigation against the company, “particularly OceanGate’s refusal to conduct
critical, non-destructive testing of the experimental design of the hull.”
Lochridge, a submersible
pilot hired to do quality and safety inspections, said he was terminated for
coming forward. He said he disagreed with Rush’s decision to “subject
passengers to potential extreme danger in an experimental submersible.” In
court papers, OceanGate denied Lochridge’s claims, and the case was later
settled.
Rush had criticized what
he considered red tape. “One of the jabs that gets thrown at us is: ‘Hey, you
aren’t certified.’ But how can you do something new and get certified?” Rush
asked in a 2022 article in Maptia. “If the rules exist for how to do it, then
you are operating outside of the rules by doing something different.”
Referring to Gen.
Douglas MacArthur, he added: “I think it was MacArthur who said, ‘You are
remembered for the rules you break.’ We try to break the rules intelligently
and intentionally.”
1) SAFF
Championships 2023: India’s draw against Kuwait feels like a loss, says skipper
Sunil Chhetri:
India skipper Sunil Chhetri celebrates after scoring the opening goal against Kuwait during the SAFF Championship 2023 match in Bengaluru on Tuesday
Chhetri bagged his 92nd international goal but saw his team succumb to a 1-1 draw against Kuwait, courtesy of a late own goal by Anwar Ali.
Indian football team
captain Sunil Chhetri did what he does best – score goals. But, against Kuwait,
it was not enough. Getting at the end of a pinpoint ball by Thapa, the Indian
skipper rattled the net on the volley to give India a 1-0 lead in the dying
stages of the first-half.
Chhetri bagged his 92nd
international goal but saw his team succumb to a 1-1 draw, courtesy of a late
own goal by Anwar Ali.
The last time India
played Kuwait was in an international friendly in 2010, where the Blue Tigers
suffered a 9-1 humiliation. From that result to holding the Al-Azraqs to a 1-1
draw has surely been an improvement. However, Chhetri was not satisfied. “The
feeling that comes to my mind right is a feeling of loss because, at the last
moment, we conceded that goal. But I am sure we did a lot of good things. When
we watch the video analysis, we will come to know better,” the Indian skipper
said after the match. “To a large extent, we could do what we had trained for.
They are not an easy side. This team can play, and we can see that. But for the
majority of the time. I think we did well, but right now, I can’t say much
about it. Once we see the video, we will probably know it better.”
Chhetri on Stimac’s
red card
The match against Kuwait
was an ill-tempered one, with India head coach Igor Stimac seeing a red card
for dissent. It is the Croat’s second red card in the tournament, having
already seen the first one in India’s 2023 SAFF Championship opener against
Pakistan.
By the time Stimac saw
the red card in the 81st minute, Chhetri had already been substituted. Asked
about what exactly transpired leading up to the red, he said, “I have no idea.
I came to the party late. I was right there [in the dugout], but by the time I
had arrived at the scene, everything had already happened. We haven’t talked
about it. We generally don’t talk about games right after the match. We will
recuperate, and then we will see.”
2) Sutirtha-Ayhika
pair clinches WTT Contender title:
Sutirtha Mukherjee and
Ayhika Mukherjee overwhelmed the Japanese pair of Miyuu Kihara and Miwa
Harimoto 3-1 to win the WTT Contender Tunis Women’s Doubles title at the Sports
Hall of Rades in Tunisia on Sunday. The pair thus became the first Indian table
tennis players to clinch a WTT Contender title this year.
The Indian duo played an
attacking game and won the first two games easily. The Japanese pair rallied
back in the third game Sutritha and Ayhika kept their cool and won the fourth
game to win the title 11-5, 11-6, 5-11, 13-11. in the final. Harimoto won the
women’s singles title at Tunis earlier in the day.
On the way to the title
clash, Sutirtha and Ayhika turned out to be giant killers as they stunned
top-seeds and world championships silver medallists Shin Yubin and Jeon Ji-hee
of Korea in the semis.
Earlier, they accounted
for bronze medallists from the 2022 world championships Chinese Taipei’s Chen
Szu-Yu and Huang Yi-Hua, after beating Amy Wang and Rachel Sung of the USA in
the opening round.
In the mixed doubles
event, the pair of Manika Batra and Sathiyan Gnanasekaran made the semi-finals
before going down to Shin Yubin and Lim Jonghoon of Korea on Saturday.
The men’s doubles pair
of Manav Vikash Thakkar and Manush Utpalbhai Shah also made the final four
before going down to the Korean pair of Cho Daeseong and Cho Seungmin.
Commonwealth Games 2022
champion Sharath Kamal and compatriot Sathiyan Gnanasekaran were eliminated in
the first round of singles. Harmeet Desai crashed out in the pre-quarterfinals.
In the women’s singles
category, Manika Batra lost in the first round. Tokyo Olympian Ayhika Mukherjee
was the only Indian women’s player to make the second round.
Results of other Indian
players: Sanil Shetty,Manush Shah (failed to qualify)
Women’s singles: Diya
Parag Chitale Sreeja Akula (lost in the first round), Reeth Tennison, Sutirtha
Mukherjee (failed to qualify)
Men’s doubles: Harmeet
Desai/Sharath Kamal (lost in the first round)
Women’s doubles: Diya
Parag Chitale/Sreeja Akula – Out in the first round.
3) Special Olympic
World Games: India end with whopping 202 medals, including 76 gold:
India secured 76 gold,
75 silver and 51 bronze medals in the global multi-sport spectacle that
celebrates unity, diversity and special skills among people with intellectual
disabilities. Berlin: India ended their Special Olympics World Games campaign
with a whopping 202 medals, including 76 gold, with the last pair of yellow metal
coming from athletics in Berlin.
The Indian athletes
bagged six medals from the track events (2 gold, 3 silver, 1 bronze) on the
concluding day on Sunday with Aanchal Goyal (400m, Level B Female) and
Ravimathi Arumugam (400m, Level C Female) standing on top of the podium.
Saket Kundu, who had
earlier grabbed a silver medal in the mini javelin Level B, also won a bronze
in the Level B 400m race, a rare double in track and field India secured 76
gold, 75 silver and 51 bronze medals in the global multi-sport spectacle that
celebrates unity, diversity and special skills among people with intellectual
disabilities.
The Indians were among a
host of participants who later in the day took part in an evocative, emotional
and triumphant closing ceremony at the Brandenburg gate in the centre of the
historic city.
Speaking about the
Indian contingent’s performance at the Games, Special Olympics Bharat
chairperson Mallika Nada said, “A huge number of our athletes have faced social
discrimination of various forms, and are regarded as non functioning members of
society in various quarters.
“It is an obsolete
thought, and an inaccurate one too. Their performance in the sporting arena
prove that they are capable of great feats, or strength, speed, concentration
and discipline. And I hope this opens the eyes of those on the outside and
proves that we need to expand this movement further and make it more
inclusive.”
The Indian contingent is
made up of 198 athletes and unified partners and 57 coaches who competed in 16
sports.
4)Modest start by
Indian golfers; Pranavi, Vani best among them in Finland:
Diksha Dagar of India in action
A week after winning her
second Ladies European Tour title, it was not the best of starts for Indian
golfer Diksha Dagar as she was tied 90th after a storm-hit opening day on Friday.
Diksha’s fellow Indian golfers had decent starts at the Ladies Open by Pickala
Rock Resort.
The day’s proceedings
were hindered by not one but two storm delays and it took a toll on many
players.Diksha, who had 13 birdies and an eagle last week, had no birdies in
her round of 74 and will need a solid second round to make the cut.Pranavi Urs,
playing on a sponsor’s exemption, shot even par 72 and was T-55, as was Vani
Kapoor. Amandeep Drall and Ridhima Dilawari (73) were T-78th while Tvesa Malik
and Diksha, with 74 each, were T-90.But with the scoreboard rather tight, a
good round could see the Indians make the cut.Pranavi had two birdies against
two bogeys. Ridhima Dilawari had as many as five birdies, but also gave away
three bogeys and a double bogey.Carmen Alonso of Spain stormed into an early
lead after firing a magnificent 64 (-8). She capitalised on her late start and
missed the storm delays to fire birdies and one eagle to lead the field.One
back from Alonso is Austrian Christine Wolf, who after her first and only win
on the LET in Hero Indian Open some years back, is still looking for her second
win.
Starting on the
back-nine, the one-time LET winner posted birdies on the 12th, 13th, and 17th
before play came to a halt following an electrical storm. After a three hour
delay, Wolf kept her composure to birdie the third, fifth and seventh holes
before setting up another on the ninth following a fine approach.Hot on Wolf’s
heels in T3 on six-under-par 66 were Finland’s Linda Osala and Sweden’s Johanna
Gustavsson.
5) Neeraj Chopra
wins gold medal in Lausanne Diamond League with 86.77-metre throw:
The 25-year-old Chopra
had skipped three top events due to a muscle strain he sustained while training
last month but came back with a bang as he won the Diamond League title here
with his fifth-round throw of 87.66m.
Olympic champion Neeraj
Chopra continued his tremendous form as he came back from a one-month injury
lay-off to clinch the top spot in the Lausanne leg of the Diamond League, his
second straight win of the season in the prestigious one-day meeting series, on
Friday.
The 25-year-old Chopra
had skipped three top events due to a muscle strain he sustained while training
last month but came back with a bang as he won the Diamond League title here
with his fifth-round throw of 87.66m. He began with a foul and then had 83.52m
and 85.04m throws. He had another foul in the fourth round before coming up
with his winning throw of 87.66m next. His sixth and last throw was 84.15m. The
Indian superstar had won the season-opening Diamond League meeting in Doha on
May 5 with a throw of 88.67m. He has a personal best of 89.94m. In the men's
long jump, India's Murali Sreeshankar finished fifth with a below-par jump of
7.88m which he achieved in the third round.
The 24-year-old
Sreeshankar, who had clinched the third spot in the Paris leg on June 9 for his
maiden Diamond League podium finished had produced a career-best 8.41m during
the National Inter-State Championships in Bhubaneswar earlier this month.
1) Lust Stories 2:
Lust Stories 2 primarily
narrates the stories from a female perspective; it explores modern-day
relationships through the lens of sexuality and physical desires. The anthology
has been directed by four skilled filmmakers and each brings a different story
and perspective on how a woman’s sexuality is commonly looked at in our society
and what needs to be changed.
Lust Stories 2 is
beautifully directed, and the storylines of all the stories are just amazingly
curated. Like the previous season of Lust Stories, there were a few hits and a
few misses in the second season as well. But to sum it up, it is definitely
worth a watch.
2) Night Manager 2
:
John le Carré's, 'The
Night Manager', has been adapted into a Hindi version by The Ink Factory and
Banijay Asia. Sandeep Modi serves as the series creator, while Priyanka Ghose
takes on the role of director. Aditya's character is prepared for his mission,
but he will encounter unexpected challenges while attempting to expose Anil and
his illegal activities. 'The Night Manager' Season 2 will premiere on June 30,
2023, exclusively on Disney+ Hotstar
3) Shibpur:
Shibpur is a Bengali
movie released on 30 Jun, 2023. The movie is directed by Arindam Bhattacharya
and featured Parambrata Chattopadhyay, Swastika Mukherjee, Mamata Shankar and
Susmita Chatterjee as lead characters. Other popular actors who were roped in
for Shibpur are Rajatava Dutta, Kharaj Mukherjee, Sumit Samaddar, Rajatabha
Dutta and Akshay Kapoor..
Cast & Crew
Arindam Bhattacharya
Director
Parambrata Chattopadhyay
Actor
Swastika Mukherjee
Actor
Mamata Shankar
4) Satya Prem Ki
Katha:
A young dreamer
Satyaprem gets married to the woman he loves, Katha, but she`s holding on to a
secret that`s not easy to let go of. What will happen when Sattu uncovers the
truth?
Book Of This Week:
The Mystic Sinners
by Proyashi Barua
The Mystic Sinners, a
rare work of fiction on mysticism and tantra, based on extensive research done
by the author, is now available in audio format as well. The book was already
available in print and electronic formats. For her research, Barua traveled
extensively to the two main centers of tantra in India–Varanasi, and Kamakhya,
and put together a formidable storyline around the facts, making the book an
unputdownable read, and a good beginner's guide to the world of tantra and
mysticism.
Maya and Kamakshi suffer
at the behest of tantrics. Their friend Ranbeer, a filmmaker, starts work on an
investigative documentary to expose those who misuse occult practices.
Unknowingly, they embark onto a trail of the biggest undiscovered secret of
ancient India's esoteric practices. As they progress, the mystery thickens and
takes them to hotbeds of occult practices - Banaras, Kamakhya and even Yana,
where they witness eerie aghori rituals, mystical sanyasis and tantric sex.
Soon, a series of uncanny threats emerge, from severed heads of endangered
species to the abduction of those who help the trio, and a tsunami of trouble
hits them as they run helter-skelter for cover. Will they succeed in unearthing
the secret and the mystic sinners behind it? Or will they entangle themselves
in an unholy Nexus?
MORE ON PROYASHI
BARUA
Proyashi Barua is a Guwahati-based content
writer and consultant. An alumnus of Symbiosis Institute of Media and
Communication (SIMC), she has worked for about fifteen years in the
communications and media industry including The Times of India, Hindustan
Times, and an international foreign trade magazine where she served in the
capacity of an assistant editor. She also has a keen interest in learning about
the probable causes that led to the extinction of some important ancient and
medieval civilisations. Astrology, numerology and music are some pastimes that
fill her soul. Incidentally, Proyashi was the only author from Assam to
participate as a speaker/panelist at the prestigious Mystic Kalinga Festival (a
festival on mystic literature, verse and music) organised at Bhubaneswar last
year in February by the directors of Kalinga Literature Festival (KLF). About
the Publisher: Readomania is an independent publishing company based in New
Delhi. Established in September 2014, the house publishes an eclectic mix of
fiction and non-fiction, with a focus on new writing and new voices from the
region.
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